If the condition of diabetes is poorly controlled for a long time, excessive blood sugar and blood pressure in the body will continue to damage the blood vessels of the kidneys, increase the load of the kidneys to filter blood, and cause kidney disease over time. When the metabolic function of the kidney is lost by more than 90%, it becomes uremia, and the patient needs to receive dialysis treatment (dialysis) or kidney transplantation.
What are the causes of diabetic nephropathy?
Hyperlipidemia:Hyperlipidemia associated with diabetes changes the structure of the cell membrane of the kidney spheroid, thus accelerating the progression of kidney disease.
Hypertension:Hypertension itself and various growth factors can cause changes in the microvascular status of the glomerulus of the kidney. For example, the increase in renal thyroid arteriolar pressure and the increase in the tension of the renal spheroid microvascular wall accelerate the development of glomerular sclerosis and renal failure.
Hyperglycemia:A long-term hyperglycemic diet combines glucose with proteins, fats, and nucleic acids in blood or tissues, and then through a series of chemical reactions to form irreversible glycosylation end products—AGEs, AGEs, and The combination of AGE receptors on phagocytic cells and renal glomerocytes induces the secretion of various growth factors, angiotensin and cytokines, which leads to renal glomerular lesions, proteinuria, renal tubules and renal interstitial fibrosis, the most serious Even leading to kidney failure.